For over 20 years, GMT has been manufacturing and supplying worldwide Calcium Folinate.

Folates are a class of water soluble compounds belonging to the Vitamin B complex which are essential for a number of metabolic functions, including processes involved in the development and metabolism of CNS and the production of DNA and RNA, primarily in infancy, adolescence and pregnancy.
Reduced folates are manufactured at GMT, inspected and supplied at the highest quality standards in accordance with all regulatory requirements.

Calcium folinate hydrate/Leucovorin Calcium is a reduced derivative of Folic Acid which is widely used in various therapies.


Calcium Folinate is mainly used for colorectal cancer treatment in association with
5-fluorouracil and Oxaliplatin (FOLFOX egimen) or with 5-fluorouracil and Irinotecan (FOLFIRI regimen).
Additionally, it is administered as salvage therapy to reduce toxic effects after high doses of Methotrexate in the treatment of some neoplastic diseases, rheumatoid arthritis or severe psoriasis.
Calcium Folinate is also given to treat anemia caused by folate deficiency.


CAS Number :

1492-18-8 (according to USP), 2060570-47-8 (according to EP)

Formula :


Molecular Weight :

511.5 (anhydrous substance)



US-DMF # 033740


No. R1-CEP 2004-009-Rev 03



Taiwan DMF :


Canada :

DMF 2007-190

Calcium folinate - GMT Fine Chemicals SA


  • Reduced folates

Detailed use

  • Colorectal cancer, salvage therapy for oncological therapies and neoplastic disease, anemia

Therapeutic area

  • Oncology
  • detoxifying agents for antineoplastic treatment
  • vitamin and antianemic preparations
  • women’s health
  • coadjuvant for hormonal contraceptive


  •  Leucovorin calcium
  • (6RS)-N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • Calcium Leucovorin
  • Folinic Acid Calcium salt
  • Calcium (2S)-2-[4[[[(6RS)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl] methyl]amino]benzamido]pentanedioate hydrate
  • Calcium [4-({[(RS)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl] methyl}amino)benzoyl]-L-glutamate
  • L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)