For over 20 years, GMT has been manufacturing and supplying worldwide Calcium Levofolinate.

Folates are a class of water soluble compounds belonging to the Vitamin B complex which are essential for a number of metabolic functions, including processes involved in the development and metabolism of CNS and the production of DNA and RNA, primarily in infancy, adolescence and pregnancy.  

Reduced folates are manufactured at GMT, inspected and supplied at the highest quality standards in accordance with all regulatory requirements.

Calcium levofolinate hydrate/Levoleucovorin Calcium is a biologically active form of folate derivative used in different pharmaceutical products for various therapies.  


Calcium Levofolinate is used to reduce the toxic effects of some oncological therapies such as Methotrexate and other medicines (Folic Acid antagonists). It is also prescribed to treat anemia caused by folate deficiency and in synergistic combination with the chemotherapy agent 5-fluorouracil in treating colorectal cancer (FOLFOX or FOLFIRI regimen). 


CAS Number :

Formula :

Molecular Weight :

80433-71-2 (not for EP)


511.5 (anhydrous substance)



US-DMF # 025198


R1-CEP 2008-320 Rev 04


230MF10073 and 218MF10307

Calcium levofolinate - GMT Fine Chemicals SA


  • Reduced folates

Therapeutic area

  • Antianemic preparations
  • detoxifying agents for antineoplastic treatment
  • Vitamin preparations


  • (6S)-calcium folinate
  • (6S)-N5-formyl-5,6,7,8-tetrahydrofolic acid
  • (6S)-N5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid, calcium salt 
  • Levoleucovorin calcium
  • Calcium (6S)-folinate
  • (6S)-N5-formyl-5,6,7,8-tetrahydrofolic acid
  • L-glutamic acid, N-[4-[[[(6S)-2-amino-5-formyl-3,4,5, 6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-, calcium salt (1:1) 
  • Calcium (2S)-2-[[4[[[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl]amino]benzoyl]amino]pentanedioate 
  • Calcium N-{p-[[[(6S)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl] methyl]amino]benzoyl}-L-glutamate (1:1)